The Nanophysiology of Fast Transmitter Release
نویسندگان
چکیده
منابع مشابه
The Nanophysiology of Fast Transmitter Release
Action potentials invading the presynaptic terminal trigger discharge of docked synaptic vesicles (SVs) by opening voltage-dependent calcium channels (CaVs) and admitting calcium ions (Ca(2+)), which diffuse to, and activate, SV sensors. At most synapses, SV sensors and CaVs are sufficiently close that release is gated by individual CaV Ca(2+) nanodomains centered on the channel mouth. Other sy...
متن کاملCalcium and transmitter release.
The mechanism of transmitter release by intracellular Ca has been explored by recording presynaptic Ca concentration ([Ca2+]i) with Ca-sensitive fluorescent dyes and by controlling [Ca2+]i with photosensitive Ca chelators. [Ca2+]i decays slowly (in seconds) after presynaptic action potentials, while transmitter release lasts only a few ms after each spike at fast synapses. Simulations of Ca dif...
متن کاملQuantitative Aspects of Transmitter Release
The opener-stretcher motor neuron in crayfish makes 50 endings upon each of 1200 muscle fibers. We have calculated the quantal content of junctional potentials produced by individual terminals and by the whole cell at various physiological frequencies. The results show that when the motor neuron is active at 20 impulses/second, it releases 50 quanta/impulse per muscle fiber, or a total of 4.5 x...
متن کاملTransmitter release at the neuromuscular junction.
NATIONAL REVIEW OF 105 OBIOLOGY, VOL. 75 Copyright 2006, Elsev All rights re 0.1016/S0074-7742(06)75006-1 0074-7742/06 II. P hysiological Properties of Transmitter Release III. E xperimental Advantages and Limitations of the Fly NMJ A. C a2þ Measurements B. D ye Loading C. A lternative Measures of Exocytosis IV. H ow Do Vesicles Fuse: Full Fusion or Kiss-and-Run? V. C ore Machinery of Exocytosi...
متن کاملNanodomain coupling explains Ca2+ independence of transmitter release time course at a fast central synapse
A puzzling property of synaptic transmission, originally established at the neuromuscular junction, is that the time course of transmitter release is independent of the extracellular Ca(2+) concentration ([Ca(2+)]o), whereas the rate of release is highly [Ca(2+)]o-dependent. Here, we examine the time course of release at inhibitory basket cell-Purkinje cell synapses and show that it is independ...
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ژورنال
عنوان ژورنال: Trends in Neurosciences
سال: 2016
ISSN: 0166-2236
DOI: 10.1016/j.tins.2016.01.005